Article

Production of an interleukin-10 blocking antibody by genetically engineered macrophages increases cancer cell death in human gastrointestinal tumor slice cultures

2022-11-17

Abstract excerpt

<title>Abstract</title> <p>Although it can promote effector T cell function, the summative effect of interleukin-10 (IL-10) in the tumor microenvironment (TME) appears to be suppressive; therefore, blocking this critical regulatory cytokine has therapeutic potential to enhance antitumor immune function. As macrophages efficiently localize to the TME, we hypothesized that they could be used as a delivery vehicle f...

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Literature Corpus work: cb1301e3-48b2-5ec0-a6e7-0f28dca3fa84
DOI: 10.21203/rs.3.rs-2274380/v1

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