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High genetic loading of schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis

2017-11-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Importance</h4> Lithium is a first-line mood stabilizer for the maintenance treatment of Bipolar Disorder (BPD). However, the efficacy of lithium varies widely, with a non-response rate of up to 30%. Biological response markers and predictors are lacking. <h4>Objective</h4> Genetic factors are thought to mediate lithium treatment response, and the previously reported genetic overlap betwee...

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Literature Corpus work
cad9cb85-d4f0-5851-bce8-0dec70487ac6
DOI
10.1101/209270
Open publication

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High genetic loading of schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysisDOI 10.1101/209270
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