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Article

Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder

2018-10-22

Abstract excerpt

<h4>Background</h4> Lithium is a first-line medication for bipolar disorder (BD), but only ~30% of patients respond optimally to the drug. Since genetic factors are known to mediate lithium treatment response, we hypothesized whether polygenic susceptibility to the spectrum of depression traits is associated with treatment outcomes in patients with BD. In addition, we explored the potential molecular underpinning...

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Literature Corpus work
2745baf7-2cb8-5e77-87f3-cba7e477afac
DOI
10.1101/449363
Open publication

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Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorderDOI 10.1101/449363
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