Article

Refined detection and phasing of structural aberrations in pediatric acute lymphoblastic leukemia by linked-read whole genome sequencing

2018-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Structural chromosomal rearrangements that may lead to in-frame gene-fusions represent a leading source of information for diagnosis, risk stratification, and prognosis in pediatric acute lymphoblastic leukemia (ALL). However, short-read whole genome sequencing (WGS) technologies struggle to accurately identify and phase such large-scale chromosomal aberrations in cancer genomes. We therefore ev...

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Literature Corpus work: cad7f23a-8dc0-580c-9742-ef79174a19ea
DOI: 10.1101/375659

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