Article

Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis

2020-05-21

Abstract excerpt

Abl family kinases function as proto-oncogenes in various leukemias, and pro-tumor functions have been discovered for Abl kinases in solid tumors as well. However, a growing body of evidence indicates that Abl kinases can function to suppress tumor cell proliferation, motility, and in vivo tumor growth in some settings. To investigate the role of Abl kinases in prostate cancer, we generated Abl-deficient cells in...

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Literature Corpus work: cad28797-948e-5d04-811a-4e9fa01bb354
DOI: 10.1101/2020.05.19.104679

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