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Mechanical stress abnormalities promote chondrocyte senescence - The pathogenesis of knee osteoarthritis

23 Sept 2023

Abstract excerpt

Knee osteoarthritis (KOA) is a common chronic disease in orthopedics, which brings great pain to patients' life and spirit. Therefore, it is necessary to elucidate the pathogenesis of KOA. The pathophysiology of KOA has been linked to numerous factors, including oxidative stress, apoptosis, cellular senescence, mitochondrial dysfunction, and inflammatory factors. Cellular senescence has grown in importance as a...

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PMID: 37748410
DOI: 10.1016/j.biopha.2023.115552

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