Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage

17 Jul 2024

Abstract excerpt

Abnormal epigenetics is the initial factor of the occurrence and development of osteoarthritis (OA), and abnormal mechanical load is a key pathogenic factor of OA. However, how abnormal mechanical load affects chondrocyte epigenetics is unclear. Chondrocytes reportedly respond to mechanics through the extracellular matrix (ECM), which has a role in regulating epigenetics in various diseases, and mitochondria are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Osteoarthritis Treatment and Mechanisms
Share to Peroxisome Proliferator-Activated Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39156637
DOI: 10.1016/j.isci.2024.110507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damagePMID 39156637Read ↗

Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoidsSemantic proximity Read ↗

From mechanism to medicine: The progress and potential of epigenetics in osteoarthritisSemantic proximity Read ↗

Current understanding of osteoarthritis pathogenesis and relevant new approachesSemantic proximity Read ↗

Epigenetics in osteoarthritis: Novel spotlightSemantic proximity Read ↗

Mitochondrial Genetics and Epigenetics in OsteoarthritisSemantic proximity Read ↗

Epigenetic Regulation of Chondrocytes and Subchondral Bone in OsteoarthritisSemantic proximity Read ↗

The role of epigenetics in osteoarthritis: current perspective.Semantic proximity Read ↗

Quantitative analysis of DNA methylation-related proteins in patients with knee osteoarthritisSemantic proximity Read ↗

Epigenetics as a Therapeutic Target in OsteoarthritisSemantic proximity Read ↗

Single-cell RNA sequencing reveals the impact of mechanical loading on knee tibial cartilage in osteoarthritisSemantic proximity Read ↗

Chromatin organization controls nuclear stiffnessSemantic proximity Read ↗

Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.