Substitutions in SurA and BamA Lead to Reduced Susceptibility to Broad Range Antibiotics in Gonococci.

Abstract excerpt

There is growing concern about the emergence and spread of multidrug-resistant Neisseria gonorrhoeae. To effectively control antibiotic-resistant bacterial pathogens, it is necessary to develop new antimicrobials and to understand the resistance mechanisms to existing antibiotics. In this study, we discovered the unexpected onset of drug resistance in N. gonorrhoeae caused by amino acid substitutions in the...

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• Azithromycin
• Bacterial Outer Membrane Proteins
• Drug Resistance, Multiple, Bacterial
• Gonorrhea
• Neisseria gonorrhoeae