Article

Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina

2023-04-18

Abstract excerpt

It is known that metabolic defects in the retinal pigment epithelium (RPE) can cause degeneration of its neighboring photoreceptors in the retina, leading to retinal degenerative diseases such as age-related macular degeneration. However, how RPE metabolism supports the health of the neural retina remains unclear. The retina requires exogenous nitrogen sources for protein synthesis, neurotransmission, and energy m...

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Literature Corpus work: ca6b3cf0-09d1-5b81-aee4-a7413f90c89e
DOI: 10.1101/2023.04.18.537355

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