Article
Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium.
EBioMedicine - 1 Feb 2017
Zhang Wenlin, Li Hongde, Ogando Diego G, Li Shimin, Feng Matthew, Price Francis W, Tennessen Jason M, Bonanno Joseph A
Abstract excerpt
Corneal endothelium (CE) is among the most metabolically active tissues in the body. This elevated metabolic rate helps the CE maintain corneal transparency by its ion and fluid transport properties, which when disrupted, leads to visual impairment. Here we demonstrate that glutamine catabolism (glutaminolysis) through TCA cycle generates a large fraction of the ATP needed to maintain CE function, and this...
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