Article

IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself

2025-06-17

Abstract excerpt

Macrophages, as key sentinel cells of the innate immune system, can retain memory of prior stimulus exposure. Interferon gamma (IFNγ) plays a central role in maintaining trained immunity in vivo and can induce potent memory in macrophages. Such memory is associated with the formation of de novo enhancers that alter gene expression responses to subsequent stimuli. However, how such enhancers are maintained after...

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Literature Corpus work: 1ce31913-82c9-5092-897d-7d75b755598d
DOI: 10.1101/2025.06.12.659073

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