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Prime-boost vaccinations with two serologically distinct chimpanzee adenovirus vectors expressing SARS-CoV-2 spike or nucleocapsid tested in a hamster COVID-19 model

2022-03-18

Abstract excerpt

<h4>ABSTRACT</h4> Two serologically distinct replication-defective chimpanzee-origin adenovirus (Ad) vectors (AdC) called AdC6 and AdC7 expressing the spike (S) or nucleocapsid (N) proteins of an early SARS-CoV-2 isolate were tested individually or as a mixture in a hamster COVID-19 challenge model. The N protein, which was expressed as a fusion protein within herpes simplex virus glycoprotein D (gD) stimulated a...

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Literature Corpus work
ca4be428-9a11-54dd-9fe9-3c1a1c705b27
DOI
10.1101/2022.03.17.484786
Open publication

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