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An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

2021-05-09

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy and the end of the COVID-19 pandemic. We recently reported the protective activity of a single-dose intranasally-administered spike protein-based chimpanzee adenovirus-vectored vaccine (ChAd-SARS-CoV-2-S) in animals, which has advanced to human trials. Here, we assessed its durability, dose-response, and...

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Identifiers and source

Literature Corpus work
c6c5883a-931c-5b11-949d-a4c75d31c778
DOI
10.1101/2021.05.08.443267
Open publication

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An intranasal vaccine durably protects against SARS-CoV-2 variants in miceDOI 10.1101/2021.05.08.443267
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