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Pre-clinical testing of two serologically distinct chimpanzee-origin adenovirus vectors expressing spike of SARS-CoV-2

2022-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Two serologically distinct chimpanzee-origin, replication-defective adenovirus (AdC) vectors expressing the spike (S) protein of an early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolate were generated and tested for induction of antibodies in young and aged mice. Both vectors induced S protein-specific antibodies including neutralizing antibodies. Levels of antibodies increa...

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Literature Corpus work
4b8b7da8-34df-50a8-a47d-329153f9d4a4
DOI
10.1101/2022.02.23.481620
Open publication

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Pre-clinical testing of two serologically distinct chimpanzee-origin adenovirus vectors expressing spike of SARS-CoV-2DOI 10.1101/2022.02.23.481620
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