Article
Bile salt hydrolase acyltransferase activity expands bile acid diversity.
Nature - 1 Feb 2024
Guzior Douglas V, Okros Maxwell, Shivel Madison, Armwald Bruin, Bridges Christopher, Fu Yousi, Martin Christian, Schilmiller Anthony L, Miller Wendy M, Ziegler Kathryn M, Sims Matthew D, Maddens Michael E, Graham Stewart F, Hausinger Robert P, Quinn Robert A
Abstract excerpt
Bile acids (BAs) are steroid detergents in bile that contribute to the absorption of fats and fat-soluble vitamins while shaping the gut microbiome because of their antimicrobial properties1-4. Here we identify the enzyme responsible for a mechanism of BA metabolism by the gut microbiota involving amino acid conjugation to the acyl-site of BAs, thus producing a diverse suite of microbially conjugated bile acids...
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