Article
Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity
18 Apr 2019
Abstract excerpt
The metagenome of the gut microbiome encodes tremendous potential for biosynthesizing and transforming small-molecule metabolites through the activities of enzymes expressed by intestinal bacteria. Accordingly, elucidating this metabolic network is critical for understanding how the gut microbiota contributes to health and disease. Bile acids, which are first biosynthesized in the liver, are modified in the gut...
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