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Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

29 Aug 2008

Abstract excerpt

Bile salt hydrolases (BSHs) catalyze the "gateway" reaction in a wider pathway of bile acid modification by the gut microbiota. Because bile acids function as signaling molecules regulating their own biosynthesis, lipid absorption, cholesterol homeostasis, and local mucosal defenses in the intestine, microbial BSH activity has the potential to greatly influence host physiology. However, the function,...

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PMID: 18757757
DOI: 10.1073/pnas.0804437105

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