Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning.

Abstract excerpt

A long-standing goal in protein science and clinical genetics is to develop quantitative models of sequence, structure, and function relationships to understand how mutations cause disease. Deep mutational scanning (DMS) is a promising strategy to map how amino acids contribute to protein structure and function and to advance clinical variant interpretation. Here, we introduce 7429 single-residue missense...

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