Article

Allele-specific rescue of neurexin behavioral phenotypes by monoamine-targeting compounds

2026-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Neurexins are synaptic adhesion molecules associated with neurologic changes in humans, including neurodevelopmental delay, autism, schizophrenia, Tourette syndrome, and seizures. The NRXN1 gene produces >100 protein isoforms through alternative promoters and extensive splicing, which are differentially impacted by NRXN1 variants found in patients. Yet pharmacologic targeting of NRXN1 isoform...

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Literature Corpus work: ca1a8f8e-6e87-5dd0-913e-efe495244b47
DOI: 10.64898/2026.02.06.703315

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