Article

Role of duplicate genes in determining the tissue-selectivity of hereditary diseases

2017-08-01

Abstract excerpt

<h4>ABSTRACT</h4> A longstanding puzzle in human genetics is what limits the clinical manifestation of hundreds of hereditary diseases to certain tissues or cell types, while their causal genes are present and expressed throughout the human body. Here we considered a possible role for paralogs of causal genes in affecting this tissue selectivity. It has been shown across organisms that paralogs can compensate for...

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Literature Corpus work: c9f12878-77c8-54ec-97f5-4ed70f0637ca
DOI: 10.1101/171090

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