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Article

Mechanisms of tissue and cell-type specificity in heritable traits and diseases.

Nature reviews. Genetics - 1 Mar 2020

Hekselman Idan, Yeger-Lotem Esti

Abstract excerpt

Hundreds of heritable traits and diseases that are caused by germline aberrations in ubiquitously expressed genes manifest in a remarkably limited number of cell types and tissues across the body. Unravelling mechanisms that govern their tissue-specific manifestations is critical for our understanding of disease aetiologies and may direct efforts to develop treatments. Owing to recent advances in high-throughput...

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PMID: 31913361
DOI: 10.1038/s41576-019-0200-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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