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Article

Differences in the evolutionary history of disease genes affected by dominant or recessive mutations.

BMC genomics - 3 Jul 2006

Furney Simon J, Albà M Mar, López-Bigas Núria

Abstract excerpt

BACKGROUND: Global analyses of human disease genes by computational methods have yielded important advances in the understanding of human diseases. Generally these studies have treated the group of disease genes uniformly, thus ignoring the type of disease-causing mutations (dominant or recessive). In this report we present a comprehensive study of the evolutionary history of autosomal disease genes separated by...

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Identifiers

PMID: 16817963
DOI: 10.1186/1471-2164-7-165
PMCID: PMC1534034

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