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Article

Comparative analysis of human tissue interactomes reveals factors leading to tissue-specific manifestation of hereditary diseases.

PLoS computational biology - 1 Jun 2014

Barshir Ruth, Shwartz Omer, Smoly Ilan Y, Yeger-Lotem Esti

Abstract excerpt

An open question in human genetics is what underlies the tissue-specific manifestation of hereditary diseases, which are caused by genomic aberrations that are present in cells across the human body. Here we analyzed this phenomenon for over 300 hereditary diseases by using comparative network analysis. We created an extensive resource of protein expression and interactions in 16 main human tissues, by...

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Identifiers

PMID: 24921629
DOI: 10.1371/journal.pcbi.1003632
PMCID: PMC4055280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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