Article

Human genetic disease is greatly influenced by the underlying fragility of evolutionarily ancient genes

2019-02-22

Abstract excerpt

The ability to predict disease association in human genes is enhanced by an evolutionary understanding. Importantly genes linked with heritable disease, particularly dominant disorders, tend to have undergone duplication in our early vertebrate ancestors, with a strong asymmetric relationship between disease-association within duplicate/paralog pairs. Using a novel phylogenetic approach, alongside a whole-genome c...

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Literature Corpus work: 0fdeac88-c2d5-51ec-9390-8aa7aa0b9b03
DOI: 10.1101/558916

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