Article

Membrane-anchored influenza neuraminidase vaccine drives human-like broadly protective B cell responses

2026-05-15

Abstract excerpt

<h4>Summary</h4> Influenza neuraminidase (NA) is a promising target for universal flu vaccines, yet eliciting potent B-cell responses against its conserved epitopes remains challenging. Here, we developed a membrane-anchored, folding-domain-free NA (mNA) that elicited superior head-specific germinal center B cell and antibody responses compared to soluble tetrameric NA. In non-human primates, mNA immunization ind...

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Literature Corpus work: c9b3b645-05f1-52fe-89b2-bb0ac7beaa7b
DOI: 10.64898/2026.05.13.724804

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