Article

Redundant roles of YES and SRC tyrosine kinases in driving malignant peripheral nerve sheath tumors

2026-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive soft tissue sarcomas that are largely incurable with no clinically effective systemic therapies or immunotherapies for advanced disease. Here, we identify the SRC-family kinases (SFKs) YES and SRC as redundant, essential drivers of MPNST growth. Dual inhibition of YES/SRC activity by genetic silencing or pharmacological SFK i...

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Literature Corpus work: c9a03034-ca9e-54f0-b1cd-a25074d440a8
DOI: 10.64898/2026.02.17.706384

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