Article

Beyond the T2/Non-T2 Dichotomy: Cross-Cohort Airway Transcriptomics Reveals a Continuous Type 2 Axis and Reproducible Heterogeneity in T2-Low Asthma

2026-08-06

Abstract excerpt

<title>Abstract</title> <p>Background Asthma airway inflammation is not fully captured by the conventional binary T2/non-T2 framework. We aimed to determine whether cross-cohort airway transcriptomics could define a more reproducible inflammatory structure, including both a continuous T2-related axis and heterogeneity within T2-low disease. Methods Six GEO-derived human airway epithelial or sputum transcriptomi...

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Literature Corpus work: c973d5c6-e322-58ee-b7dd-cd3c14744679
DOI: 10.21203/rs.3.rs-9900269/v1

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