Article
Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes.
American journal of respiratory and critical care medicine - 1 Sept 2022
McDowell P Jane, Busby John, Hanratty Catherine E, Djukanovic Ratko, Woodcock Ashley, Walker Samantha, Hardman Timothy Colin, Arron Joseph R, Choy David F, Bradding Peter, Brightling Chris E, Chaudhuri Rekha, Cowan Douglas, Mansur Adel H, Fowler Stephen J, Diver Sarah E, Howarth Peter, Lordan James, Menzies-Gow Andrew, Harrison Timothy, Robinson Douglas S, Holweg Cecile T J, Matthews John G, Pavord Ian D, Heaney Liam G
Abstract excerpt
Rationale: The past 25 years have seen huge progress in understanding of the pathobiology of type-2 (T2) asthma, identification of measurable biomarkers, and the emergence of novel monoclonal antibody treatments. Although present in a minority of patients with severe asthma, very little is known about the mechanisms underlying T2-low asthma, making it a significant unmet need in asthma research. Objectives: The...
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