Article

Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling

2024-03-02

Abstract excerpt

The folate-methionine cycle (Met-C) is a central metabolic pathway that is regulated by vitamin B12 (B12), a micronutrient obtained exclusively from diet and microbiota. This metabolic hub supports amino acid, nucleotide and lipid biosynthesis apart from its central role of providing one carbon (-CH 3 ) moiety for methylation reactions. While deficiency of B12 as well as polymorphism in enzymes of the Met-C has b...

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Literature Corpus work: 2d3fb5e1-4d44-5b22-87c9-0ee89a296961
DOI: 10.1101/2024.03.01.582891

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