Article

The CRAC channel inhibitor BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entry

2025-02-24

Abstract excerpt

Human norovirus is the leading cause of viral gastroenteritis across all age groups. While there is a need for human norovirus antivirals, therapeutic development has been hindered by a lack of cell culture systems and animal models of infection. Surrogate viruses, such as Tulane virus (TV), have provided tractable systems to screen potential antiviral compounds. Our previous work demonstrated that Tulane virus en...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c92792c1-f5e8-59e5-8d6b-d5839b74c965
DOI: 10.1101/2025.02.23.639787

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The CRAC channel inhibitor BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entryDOI 10.1101/2025.02.23.639787Read

Recovirus NS1-2 has viroporin activity that induces aberrant cellular calcium signaling to facilitate virus replicationSemantic proximity Read

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatmentSemantic proximity Read

CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

A reversible broad-spectrum antiviral targets the human V-ATPase VO domainSemantic proximity Read

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2Semantic proximity Read

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307Semantic proximity Read

Norovirus: targets and tools in antiviral drug discovery.Semantic proximity Read

Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome VirusSemantic proximity Read

The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus InfectionSemantic proximity Read

Tetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling PathwaysSemantic proximity Read

Functional Analysis of Picornavirus 2B Proteins: Effects on Calcium Homeostasis and Intracellular Protein TraffickingSemantic proximity Read

Thapsigargin: key to new host-directed coronavirus antivirals?Semantic proximity Read