Article

Recovirus NS1-2 has viroporin activity that induces aberrant cellular calcium signaling to facilitate virus replication

2019-07-16

Abstract excerpt

Enteric viruses in the Caliciviridae family cause acute gastroenteritis in humans and animals, but the cellular processes needed for virus replication and disease remain unknown. A common strategy among enteric viruses, including rotaviruses and enteroviruses, is to encode a viral ion channel (i.e., viroporin) that is targeted to the endoplasmic reticulum (ER) and disrupts host calcium (Ca 2+ ) homeostasis. Prev...

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Literature Corpus work: 7a048377-e935-5d76-b377-70270188b7b6
DOI: 10.1101/703959

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