Article

A reversible broad-spectrum antiviral targets the human V-ATPase VO domain

2026-06-03

Abstract excerpt

<title>Abstract</title> <p> Increasing threats of viral disease underscore the urgent need for broad-spectrum antiviral drugs (BSADs). Host proteins utilized by human pathogenic viruses are key BSAD targets. The vacuolar-type H⁺-ATPase (V-ATPase) has been identified as a proviral factor for most pH-dependent enveloped viruses classified as pandemic threats. We report here the discovery of cladoniamide A (CA), a...

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Literature Corpus work: 5e9032ed-766e-5225-975c-ddd37b4cd5aa
DOI: 10.21203/rs.3.rs-9889115/v1

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