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Article

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307

11 Jan 2017

Abstract excerpt

The genus Enterovirus (e.g. poliovirus, coxsackievirus, rhinovirus) of the Picornaviridae family of positive-strand RNA viruses includes many important pathogens linked to a range of acute and chronic diseases for which no approved antiviral therapy is available. Targeting a step in the life cycle that is highly conserved provides an attractive strategy for developing broad-range inhibitors of enterovirus...

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PMID: 28088354
DOI: 10.1016/j.antiviral.2017.01.008

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