Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence

Abstract excerpt

Bisphosphonates (BPs) have been the major class of medicines used to treat disorders of excessive bone loss for over five decades. Recently it has been recognized that BPs may also have additional significant beneficial extra-skeletal effects. These include a reduction of all-cause mortality and of conditions commonly linked to ageing, such as cancer and cardiovascular disease. Here we show that bisphosphonates co...

Topics

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• Amino Acid Enzymes and Metabolism
• Autophagy in Disease and Therapy
• Bone Metabolism and Diseases
• Metabolism, Diabetes, and Cancer
• MicroRNA in disease regulation
• Muscle Physiology and Disorders
• Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

c905dd0f-0e7c-512b-a373-de0c4b3b2907

DOI

10.1101/2025.03.25.645228