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Single cell RNA sequence combined with bulk RNA sequence to construct and validate a novel prognostic signature based on cell developmental trajectory- related genes to predict prognosis and immunotherapeutic response in Hepatocellular Carcinoma

2022-11-29

Abstract excerpt

<h4>Background: </h4> Immunotherapy is the first-line treatment for advanced liver cancer. However, there is a dearth of validated molecular indicators to predict immunotherapy response. <h4>Methods: </h4>: Through a combined analysis of bulk RNA sequence data from 365 HCC cases and single cell sequence data from 2 HCC cases, we created a predictive signature based on cell developmental trajectory-related genes. S...

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Literature Corpus work
c8f309fd-90ee-571c-9065-21fe45963c8a
DOI
10.21203/rs.3.rs-2293095/v1
Open publication

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Single cell RNA sequence combined with bulk RNA sequence to construct and validate a novel prognostic signature based on cell developmental trajectory- related genes to predict prognosis and immunotherapeutic response in Hepatocellular CarcinomaDOI 10.21203/rs.3.rs-2293095/v1
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