Single-cell sequencing and bulk RNA sequencing reveal a cell differentiation-related multigene panel to predict the prognosis and immunotherapy response of hepatocellular carcinoma

Abstract excerpt

To the Editor: Hepatocellular carcinoma (HCC) is the sixth most common tumor and the third leading cause of cancer death globally in 2020.[1] The lack of early diagnosis and high intratumoral heterogeneity in HCC are important reasons for its high mortality. Genetic susceptibility and environmental stimuli lead to a tumor mass consisting of mixed tumor cells with different differentiation characteristics. Thus,...

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