Article

Establishment of a patient-derived malignant peripheral nerve sheath tumor organoid model reveals SHH pathway activation and therapeutic vulnerability

2026-04-22

Abstract excerpt

<title>Abstract</title> Malignant peripheral nerve sheath tumor (MPNST) is a rare and aggressive soft tissue sarcoma of presumed peripheral nerve sheath origin, for which effective systemic therapies remain limited. The biological mechanisms underlying its progression and therapeutic vulnerabilities are not fully understood, partly due to the lack of reliable patient-derived models. In this study, we attempt...

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Literature Corpus work: 7b3d4a7f-98dd-5279-b314-a197bd6da73d
DOI: 10.21203/rs.3.rs-9404926/v1

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