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Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis

6 Feb 2016

Abstract excerpt

Neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN) are tumor-suppressor syndromes. Each syndrome is an orphan disease; however, the tumors that arise within them represent the most common tumors of the nervous system worldwide. Systematic investigation of the pathways impacted by the loss of function of neurofibromin (encoded byNF1) and merlin (encoded byNF2) have led to...

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PMID: 26851632
DOI: 10.1093/neuonc/nov200

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