Article

PRC2 Restricts Malignant Peripheral Nerve Sheath Tumorigenesis in a Genetically Engineered Mouse Model of MPNST

2025-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Polycomb Repressive Complex 2 (PRC2), which normally regulates transcriptional silencing, chromatin compaction, and stem cell biology, has both oncogenic and tumor suppressor roles in cancer development depending on tumor type. Malignant peripheral nerve sheath tumor (MPNST), characterized by NF1, CDKN2A and PRC2 loss, is an aggressive subtype of sarcoma with poor prognosis and no effective the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca4a4869-92fa-5ed1-bce6-a51b293f8363
DOI: 10.1101/2025.11.12.687881

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PRC2 Restricts Malignant Peripheral Nerve Sheath Tumorigenesis in a Genetically Engineered Mouse Model of MPNSTDOI 10.1101/2025.11.12.687881Read

The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor.Semantic proximity Read

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.Semantic proximity Read

Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumorSemantic proximity Read

Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state.Semantic proximity Read

A Sequencing Overview of Malignant Peripheral Nerve Sheath Tumors: Findings and Implications for TreatmentSemantic proximity Read

Integrated Proteomic and Epigenomic Analysis Reveals IGF2 as a Vulnerability in PRC2-Deficient Malignant Peripheral Nerve Sheath TumorsSemantic proximity Read

Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define premalignant neurofibromatosis type 1–associated atypical neurofibromasSemantic proximity Read

Identification of Malignant Peripheral Nerve Sheath Tumor subtypes with distinct genomic identitiesSemantic proximity Read

PRC2 loss drives MPNST metastasis and matrix remodeling.Semantic proximity Read

Genomic patterns of malignant peripheral nerve sheath tumour (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNASemantic proximity Read

From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor.Semantic proximity Read

Malignant peripheral nerve sheath tumor in children: A clinicopathologic and molecular study with parallels to the adult counterpart.Semantic proximity Read