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Article

Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis.

Cell death & disease - 10 Feb 2021

Lou Yuqing, Xu Jianlin, Zhang Yanwei, Zhang Wei, Zhang Xueyan, Gu Ping, Zhong Hua, Wang Huimin, Lu Jun, Han Baohui

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a key oncogene in lung adenocarcinoma (LUAD). Resistance to EGFR tyrosine kinase inhibitors is a major obstacle for EGFR-mutant LUAD patients. Our gene chip array, quantitative polymerase chain reaction validation, and shRNA-based high-content screening identified the Akt kinase lanthionine synthetase C-like protein 2 (LANCL2) as a pro-proliferative gene in the...

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PMID: 33568630
DOI: 10.1038/s41419-021-03439-8
PMCID: PMC7876134

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