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Article

KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation

30 Jan 2018

Abstract excerpt

The coxsackievirus and adenovirus receptor (CAR) is a transmembrane receptor that plays a key role in cell-cell adhesion. CAR is found in normal epithelial cells and is increased in abundance in various human tumors, including lung carcinomas. We investigated the potential mechanisms by which CAR contributes to cancer cell growth and found that depletion of CAR in human lung cancer cells reduced...

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PMID: 29382784
DOI: 10.1126/scisignal.aaq1060

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