Article

Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells

2023-04-13

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Glioblastoma (GBM) is recognized as among the most aggressive forms of brain tumor. Patients typically present with a five-year survival rate of less than 6% with traditional surgery and chemoradiotherapy, which calls for novel immunotherapies like chimeric antigen receptor T (CAR-T) cells therapy. In response to endoplasmic reticulum (ER) stress in multiple tum...

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Literature Corpus work: c8efa851-2289-5420-964f-02945fb373cb
DOI: 10.21203/rs.3.rs-2775142/v1

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