Article

First-in-human demonstration of splenic ultrasound stimulation for non-invasively controlling inflammation

2020-07-17

Abstract excerpt

Hyperinflammation and uncontrolled cytokine release in infections and autoimmune diseases require therapy to reduce the innate immune response. Here, we present first in-human data showing reduction in pro-inflammatory cytokine release with ultrasound stimulation of the spleen in healthy subjects and in rheumatoid arthritis patients. Single cell RNA sequencing reveals a decrease in IL-1β and IL-8 transcript levels...

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Literature Corpus work: 5772c5de-41f5-59cc-9c7a-41e257db7de6
DOI: 10.1101/2020.07.14.20153528

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