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Protective association of <i>HLA-DRB1</i>*04 subtypes in neurodegenerative diseases implicates acetylated Tau PHF6 sequences

2021-12-30

Abstract excerpt

Using genome-wide association data, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s (PD) or Alzheimer’s (AD) disease versus controls across ancestry groups. A shared genetic association was observed across diseases at rs601945 (PD: odds ratio (OR)=0.84; 95% confidence interval, [0.80; 0.88]; p=2.2×10 −13 ; AD: OR=0.91[0.89; 0.93]; p=1.8×10 −22 ), and with a prote...

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Identifiers and source

Literature Corpus work
c8d44135-8052-51ad-833b-b281e27bc6e4
DOI
10.1101/2021.12.26.21268354
Open publication

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Protective association of <i>HLA-DRB1</i>*04 subtypes in neurodegenerative diseases implicates acetylated Tau PHF6 sequencesDOI 10.1101/2021.12.26.21268354
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