Developing an evolutionary baseline model for humans: jointly inferring purifying selection with population history

Abstract excerpt

<h4>ABSTRACT</h4> Building evolutionarily appropriate baseline models for natural populations is not only important for answering fundamental questions in population genetics – including quantifying the relative contributions of adaptive vs. non-adaptive processes – but it is also essential for identifying candidate loci experiencing relatively rare and episodic forms of selection ( e.g., positive or balancing s...

Topics

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• Demography
• Evolution, Molecular
• Gene Frequency
• Genetic Drift
• Genetics, Population
• Genome, Human
• Models, Genetic
• Selection, Genetic

Identifiers and source

Literature Corpus work

c8d00147-30d6-531f-9c86-f4369a11f780

DOI

10.1101/2023.04.11.536488