Toward an Evolutionarily Appropriate Null Model: Jointly Inferring Demography and Purifying Selection.

Abstract excerpt

The question of the relative evolutionary roles of adaptive and nonadaptive processes has been a central debate in population genetics for nearly a century. While advances have been made in the theoretical development of the underlying models, and statistical methods for estimating their parameters from large-scale genomic data, a framework for an appropriate null model remains elusive. A model incorporating...

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