Back to search

Article

Prognostic impact of RUNX1 mutations and deletions in pediatric acute myeloid leukemia: results from the French ELAM02 study group

2022-10-10

Abstract excerpt

<title>Abstract</title> <p>Better knowledge of genetic aberrations in pediatric acute myeloid leukemia is essential to adapt treatment intensity. RUNX1 mutations are well described in adult AML and known to be associated with a poor outcome. In children, first studies showed similar results but because of their low frequency, prognosis impact remains unclear. RUNX1 deletions have rarely been described. Among 386...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c8c4fe47-7aa0-5269-9bd1-1cdb6bb5e7b8
DOI
10.21203/rs.3.rs-2095753/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Prognostic impact of RUNX1 mutations and deletions in pediatric acute myeloid leukemia: results from the French ELAM02 study groupDOI 10.21203/rs.3.rs-2095753/v1
RUNX1 mutation has no prognostic significance in paediatric AML: A retrospective study of the AML-BFM study groupSemantic proximity
Molecular Profiling Defines Distinct Prognostic Subgroups in Childhood AML: A Report From the French ELAM02 Study GroupSemantic proximity
RUNX1 mutation has no prognostic significance in paediatric AML: a retrospective study of the AML-BFM study group.Semantic proximity
Molecular Characterization of Pediatric Acute Myeloid Leukemia: Results of a Multicentric Study in Brazil.Semantic proximity
RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis.Semantic proximity
RUNX1 mutations in pediatric acute myeloid leukemia are associated with distinct genetic features and an inferior prognosisSemantic proximity
AML1/RUNX1 Mutations in 470 Adult Patients with De Novo Acute Myeloid Leukemia: Prognostic Implication and Interaction with Other Gene Alterations.Semantic proximity
Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current KnowledgeSemantic proximity
Investigations of the prognostic value of RUNX1 mutation in acute myeloid leukemia patients: Data from a real-world study.Semantic proximity
The new provisional WHO entity ‘RUNX1 mutated AML’ shows specific genetics but no prognostic influence of dysplasiaSemantic proximity
Comprehensive molecular understanding of pediatric acute myeloid leukemia.Semantic proximity
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactionsSemantic proximity
Select a neighboring publication to make it the new centre.