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Article

Comprehensive molecular understanding of pediatric acute myeloid leukemia.

International journal of hematology - 1 Feb 2023

Shiba Norio

Abstract excerpt

Pediatric acute myeloid leukemia (AML) is a heterogeneous disease with various genetic abnormalities. Recent advances in genetic analysis have enabled the identification of causative genes in > 90% of pediatric AML cases. Fusion genes such as RUNX1::RUNX1T1, CBFB::MYH11, and KMT2A::MLLT3 are frequently detected in > 70% of pediatric AML cases, whereas FLT3-internal tandem duplication, CEBPA-bZip, and NPM1...

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PMID: 36653696
DOI: 10.1007/s12185-023-03533-x

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