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Article

Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche.

Development (Cambridge, England) - 1 Aug 2012

Michel Marcus, Kupinski Adam P, Raabe Isabel, Bökel Christian

Abstract excerpt

In the Drosophila testis, germline stem cells (GSCs) and somatic cyst stem cells (CySCs) are arranged around a group of postmitotic somatic cells, termed the hub, which produce a variety of growth factors contributing to the niche microenvironment that regulates both stem cell pools. Here we show that CySC but not GSC maintenance requires Hedgehog (Hh) signalling in addition to Jak/Stat pathway activation. CySC...

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Source

Identifiers

PMID: 22745310
DOI: 10.1242/dev.075242

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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