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Population genetics without intraspecific data.

Molecular biology and evolution - 1 Aug 2007

Thorne Jeffrey L, Choi Sang Chul, Yu Jiaye, Higgs Paul G, Kishino Hirohisa

Abstract excerpt

A central goal of computational biology is the prediction of phenotype from DNA and protein sequence data. Recent models of sequence change use in silico prediction systems to incorporate the effects of phenotype on evolutionary rates. These models have been designed for analyzing sequence data from different species and have been accompanied by statistical techniques for estimating model parameters when the...

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PMID: 17470435
DOI: 10.1093/molbev/msm085

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